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. 2016 Oct:177:133-139.e1.
doi: 10.1016/j.jpeds.2016.06.045. Epub 2016 Jul 29.

Breast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks' Gestation

Mandy B Belfort  1 , Peter J Anderson  2 , Victoria A Nowak  3 , Katherine J Lee  2 , Charlotte Molesworth  2 , Deanne K Thompson  4 , Lex W Doyle  5 , Terrie E Inder  6
Affiliations

Breast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks' Gestation

Mandy B Belfort et al. J Pediatr. 2016 Oct.

Abstract

Objectives: To determine the associations of breast milk intake after birth with neurological outcomes at term equivalent and 7 years of age in very preterm infants

Study design: We studied 180 infants born at <30 weeks' gestation or <1250 grams birth weight enrolled in the Victorian Infant Brain Studies cohort from 2001-2003. We calculated the number of days on which infants received >50% of enteral intake as breast milk from 0-28 days of life. Outcomes included brain volumes measured by magnetic resonance imaging at term equivalent and 7 years of age, and cognitive (IQ, reading, mathematics, attention, working memory, language, visual perception) and motor testing at 7 years of age. We adjusted for age, sex, social risk, and neonatal illness in linear regression.

Results: A greater number of days on which infants received >50% breast milk was associated with greater deep nuclear gray matter volume at term equivalent age (0.15 cc/d; 95% CI, 0.05-0.25); and with better performance at age 7 years of age on IQ (0.5 points/d; 95% CI, 0.2-0.8), mathematics (0.5; 95% CI, 0.1-0.9), working memory (0.5; 95% CI, 0.1-0.9), and motor function (0.1; 95% CI, 0.0-0.2) tests. No differences in regional brain volumes at 7 years of age in relation to breast milk intake were observed.

Conclusion: Predominant breast milk feeding in the first 28 days of life was associated with a greater deep nuclear gray matter volume at term equivalent age and better IQ, academic achievement, working memory, and motor function at 7 years of age in very preterm infants.

Keywords: academic achievement; intelligence; magnetic resonance imaging; memory; preterm infant.

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Conflict of interest statement

The other authors declare no conflicts of interest.

References

    1. Kramer MS, Aboud F, Mironova E, Vanilovich I, Platt RW, Matush L, et al. Breastfeeding and child cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry. 2008;65:578–84. - PubMed
    1. Belfort MB, Rifas-Shiman SL, Kleinman KP, Guthrie LB, Bellinger DC, Taveras EM, et al. Infant feeding and childhood cognition at ages 3 and 7 years: Effects of breastfeeding duration and exclusivity. JAMA pediatrics. 2013;167:836–44. - PMC - PubMed
    1. Smithers LG, Kramer MS, Lynch JW. Effects of Breastfeeding on Obesity and Intelligence: Causal Insights From Different Study Designs. JAMA pediatrics. 2015;169:707–8. - PubMed
    1. Demmelmair H, Koletzko B. Importance of fatty acids in the perinatal period. World Rev Nutr Diet. 2015;112:31–47. - PubMed
    1. Britton JR, Britton HL, Gronwaldt V. Breastfeeding, sensitivity, and attachment. Pediatrics. 2006;118:e1436–43. - PubMed

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