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. 2016 Sep 23;60(10):6407-10.
doi: 10.1128/AAC.01282-16. Print 2016 Oct.

Activity of Ceftazidime-Avibactam against Clinical and Isogenic Laboratory Pseudomonas aeruginosa Isolates Expressing Combinations of Most Relevant β-Lactam Resistance Mechanisms

Gabriel Torrens  1 , Gabriel Cabot  2 , Alain A Ocampo-Sosa  3 , M Carmen Conejo  4 , Laura Zamorano  1 , Ferrán Navarro  5 , Álvaro Pascual  4 , Luis Martínez-Martínez  6 , Antonio Oliver  1
Affiliations

Activity of Ceftazidime-Avibactam against Clinical and Isogenic Laboratory Pseudomonas aeruginosa Isolates Expressing Combinations of Most Relevant β-Lactam Resistance Mechanisms

Gabriel Torrens et al. Antimicrob Agents Chemother. .

Abstract

The activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190 Pseudomonas aeruginosa clinical isolates recovered from a multicenter study of bloodstream infections. The addition of avibactam increased ceftazidime susceptibility in the complete collection of strains (64.7% to 91.1%) and particularly among subsets of isolates showing AmpC hyperproduction (10.9% to 76.1%) or multidrug resistance (MDR) profiles (27% to 77.8%). The MICs of ceftazidime-avibactam, in contrast with those of ceftazidime or meropenem, remained at ≤4 μg/ml for a panel of 16 P. aeruginosa PAO1 isogenic mutants expressing multiple combinations of the most relevant β-lactam resistance mechanisms.

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Figures

FIG 1
FIG 1
(A) Ceftazidime (CAZ) and ceftazidime-avibactam (CAZ-AVI) MIC distributions for a collection of 190 P. aeruginosa bloodstream isolates recovered from a 10-hospital multicenter study performed in Spain. (B) CAZ and CAZ-AVI MIC distribution for the 46 isolates from the collection showing AmpC hyperproduction. (C) CAZ and CAZ-AVI MIC distribution for the 63 isolates from the collection showing an MDR profile.
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