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. 2017 Jan;19(1):90-97.
doi: 10.1111/jch.12879. Epub 2016 Aug 2.

Description of Antihypertensive Medication Use in a Pediatric Practice: Single and Multiple Antihypertensive Medication Therapy

Edem Binka  1 , Susan Mendley  2 , Peter Gaskin  3 , Carisa Himes  3 , Laide Jinadu  2 , Carissa M Baker-Smith  3
Affiliations

Description of Antihypertensive Medication Use in a Pediatric Practice: Single and Multiple Antihypertensive Medication Therapy

Edem Binka et al. J Clin Hypertens (Greenwich). 2017 Jan.

Abstract

Prescription of multiple antihypertensive medications for the treatment of essential hypertension (HTN) has been well described in adults but not in children and adolescents. The authors describe the frequency with which children with essential HTN are prescribed a single vs two or more concomitantly administered antihypertensive medications. They also describe demographic features and comorbidities associated with the prescription of a single vs multiple antihypertensive medications. Multiple antihypertensive medication use in the management of pediatric HTN, as in the management of adult HTN, is not uncommon. In this single-center, retrospective study of 113 children with essential HTN, 28% of children were concomitantly prescribed two or more antihypertensive medications for poorly controlled blood pressure following prescription of a single medication. Demographic and comorbid conditions associated with the prescription of more than one antihypertensive medication include advanced hypertensive stage, race, and a family history of HTN.

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Figures

Figure 1
Figure 1
First antihypertensive agent prescribed. ACEi indicates angiotensin‐converting enzyme inhibitor; CCB, calcium channel blocker; Diuretic, thiazide diuretic/HCTZ; ARB, angiotensin receptor blocker.
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