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. 2016 Jul 29;13(8):770.
doi: 10.3390/ijerph13080770.

Prevalence and Risk Factors of Heart Failure with Preserved Ejection Fraction: A Population-Based Study in Northeast China

Liang Guo  1 , Xiaofan Guo  2 , Ye Chang  3 , Jun Yang  4 , Limin Zhang  5 , Tan Li  6 , Yingxian Sun  7
Affiliations

Prevalence and Risk Factors of Heart Failure with Preserved Ejection Fraction: A Population-Based Study in Northeast China

Liang Guo et al. Int J Environ Res Public Health. .

Abstract

Background: Heart failure with preserved ejection fraction (HFpEF) has attracted increasing attention worldwide. We aimed to estimate the prevalence of HFpEF and analyze its correlates in a sample of residents of northeast China;

Methods: A population-based study of 2230 participants ≥35 years old was conducted in rural areas of Liaoning Province from January 2012 through August 2013. Information about lifestyle and other potential risk factors was obtained. HFpEF was diagnosed according to the recommendations of European Society of Cardiology;

Results: The overall prevalence of HFpEF was 3.5% (1.8% in men and 4.9% in women). The prevalence of HFpEF increased with age in both genders and was greater in women than in men for every age group. Multivariable logistic regression analysis found that female gender (OR, 3.575; 95% CI, 1.761-7.256), hypertension (OR, 3.711; 95% CI, 2.064-6.674), and history of heart disease (2.086; 95% CI, 1.243-3.498) were associated factors for prevalent HFpEF;

Conclusions: In a general population from rural northeast China, we found that female gender, hypertension, and history of heart disease were risk factors for prevalent HFpEF.

Keywords: heart failure; preserved ejection fraction; prevalence; risk factor.

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Figures

Figure 1
Figure 1
Diagnostic flowchart of heart failure with preserved ejection fraction (HFpEF). A: atrial diastolic filling wave velocity; E: early diastolic filling wave velocity; E’: early diastolic mitral annular velocity; LV: left ventricle; DE: E wave deceleration time; LVED: left ventricular end diastolic diameter; LVEDVI: left ventricular enddiastolic volume index; LVEF: left ventricular ejection fraction; LVMI: left ventricular mass index.
Figure 2
Figure 2
The (a) prevalence and (b) standardized prevalence of HFpEF in men and women.
Figure 3
Figure 3
Prevalence of clinical co-morbidities with or without HFpEF (%) in men (a) and women (b). * p < 0.05, subjects with HFpEF vs. subjects without HFpEF.
See this image and copyright information in PMC

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