Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug 2:16:123.
doi: 10.1186/s12883-016-0640-1.

REM sleep behavior disorder was associated with Parkinson's disease: a community-based study

Jian-Fang Ma  1 , Miao-Miao Hou  1 , Hui-Dong Tang  1 , Xiang Gao  2 , Liang Liang  1 , Li-Fang Zhu  3 , Yi Zhou  1 , Sheng-Yu Zha  1 , Shi-Shuang Cui  1 , Juan-Juan Du  1 , Gen Li  1 , Jun Liu  4 , Sheng-Di Chen  5
Affiliations

REM sleep behavior disorder was associated with Parkinson's disease: a community-based study

Jian-Fang Ma et al. BMC Neurol. .

Abstract

Background: Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson's disease (PD).

Methods: The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence of pRBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China.

Results: RBD1Q-C demonstrated a high sensitivity of 100%, a moderate specificity of 55.6%. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k = 0.552). PPV of the RBD1Q-C was 63.6% and NPV was 100%. The prevalence of pRBD in Malu community was 4.9%. In people over 50 years old, presence of pRBD was significantly associated with increased risk of having PD (odds ratio = 2.61, 95% CI: 1.56-4.39).

Conclusion: RBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found that pRBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians.

Keywords: Community-based study; Parkinson’s disease; Prevalence; REM sleep behavior disorder.

PubMed Disclaimer

References

    1. American Academy of Sleep Medicine . International Classification of Sleep Disorders. 3. Darien: American Academy of Sleep Medicine; 2014.
    1. Frauscher B, Gschliesser V, Brandauer E, et al. Video analysis of motor events in REM sleep behavior disorder. Mov Disord. 2007;22:1464–1470. doi: 10.1002/mds.21561. - DOI - PubMed
    1. Iranzo A, Molinuevo JL, Santamaria J, et al. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurology. 2006;5:572–577. doi: 10.1016/S1474-4422(06)70476-8. - DOI - PubMed
    1. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38 % of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology. 1996;46:388–393. doi: 10.1212/WNL.46.2.388. - DOI - PubMed
    1. Schenck CH, Mahowald MW. REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep. 2002;25:120–138. - PubMed

Publication types