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Comment
. 2016 Aug;6(8):821-3.
doi: 10.1158/2159-8290.CD-16-0682.

Adipocytes and Neutrophils Give a Helping Hand to Pancreatic Cancers

Vincenzo Bronte  1 , Giampaolo Tortora  2
Affiliations
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Adipocytes and Neutrophils Give a Helping Hand to Pancreatic Cancers

Vincenzo Bronte et al. Cancer Discov. 2016 Aug.

Abstract

Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight. Cancer Discov; 6(8); 821-3. ©2016 AACR.See related article by Incio et al., p. 852.

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