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. 2016 Oct;15(19):2549-2550.
doi: 10.1080/15384101.2016.1214047. Epub 2016 Aug 2.

Senescence: Adaptation to DNA repair targeting drugs?

Affiliations

Senescence: Adaptation to DNA repair targeting drugs?

Olivier Coqueret. Cell Cycle. 2016 Oct.
No abstract available

Keywords: DNA damage; senescence; tumor escape; tumor suppression.

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Comment on

  • doi: 10.1080/15384101.2016.1196302

References

    1. Perez-Mancera PA, Young AR, Narita M. Inside and out: the activities of senescence in cancer. Nat Rev Cancer 2014; 14:547-58; PMID:25030953; http://dx.doi.org/10.1038/nrc3773 - DOI - PubMed
    1. Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005; 436:720-4; PMID:16079850; http://dx.doi.org/10.1038/nature03890 - DOI - PubMed
    1. Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, et al.. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002; 109:335-46; PMID:12015983; http://dx.doi.org/10.1016/S0092-8674(02)00734-1 - DOI - PubMed
    1. Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, et al.. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 2016; 530:184-9; PMID:26840489; http://dx.doi.org/10.1038/nature16932 - DOI - PMC - PubMed
    1. Vredeveld LC, Possik PA, Smit MA, Meissl K, Michaloglou C, Horlings HM, Ajouaou A, Kortman PC, Dankort D, McMahon M, et al.. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev 2012; 26:1055-69; PMID:22549727; http://dx.doi.org/10.1101/gad.187252.112 - DOI - PMC - PubMed

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