Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jul;86(14):5434-8.
doi: 10.1073/pnas.86.14.5434.

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD

H Weintraub  1 , S J Tapscott, R L Davis, M J Thayer, M A Adam, A B Lassar, A D Miller
Affiliations

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD

H Weintraub et al. Proc Natl Acad Sci U S A. 1989 Jul.

Abstract

MyoD is a master regulatory gene for myogenesis. Under the control of a retroviral long terminal repeat, MyoD was expressed in a variety of differentiated cell types by using either a DNA transfection vector or a retrovirus. Expression of muscle-specific proteins was observed in chicken, human, and rat primary fibroblasts and in differentiated melanoma, neuroblastoma, liver, and adipocyte lines. The ability of MyoD to activate muscle genes in a variety of differentiated cell lines suggests that no additional tissue-specific factors other than MyoD are needed to activate the downstream program for terminal muscle differentiation or that, if such factors exist, they are themselves activated by MyoD expression.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3026-30 - PubMed
    1. Mol Cell Biol. 1988 Jan;8(1):62-70 - PubMed
    1. Nature. 1975 Mar 27;254(5498):341-3 - PubMed
    1. Cell. 1979 Aug;17(4):771-9 - PubMed
    1. Mol Cell Biol. 1982 Sep;2(9):1044-51 - PubMed

Publication types

LinkOut - more resources