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Clinical Trial
. 2016 Nov 1;63(9):1202-1204.
doi: 10.1093/cid/ciw507. Epub 2016 Aug 2.

No Evidence of Reactivation of Hepatitis B Virus Among Patients Treated With Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection

Mark S Sulkowski  1 , Wan-Long Chuang  2 , Jia-Horng Kao  3 , Jenny C Yang  4 , Bing Gao  4 , Diana M Brainard  4 , Kwang-Hyub Han  5 , Edward Gane  6
Affiliations
Clinical Trial

No Evidence of Reactivation of Hepatitis B Virus Among Patients Treated With Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection

Mark S Sulkowski et al. Clin Infect Dis. .

Abstract

Postmarketing cases of hepatitis B virus (HBV) reactivation during hepatitis C treatment have been reported. We analyzed serum samples from patients in a clinical trial of ledipasvir-sofosbuvir in Taiwan and Korea. Of the 173 patients enrolled, 103 (60%) had been previously infected with HBV. None showed evidence of HBV reactivation.

Keywords: ALT flare; HBV reactivation; HCV/HBV coinfection.

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References

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