Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;66(5):310-5.
doi: 10.1007/s13224-015-0682-0. Epub 2015 Mar 17.

An Epidemiology Study to Determine the Prevalence and Risk Factors Associated with Recurrent Spontaneous Miscarriage in India

Ameet Patki  1 , Naveen Chauhan  2
Affiliations

An Epidemiology Study to Determine the Prevalence and Risk Factors Associated with Recurrent Spontaneous Miscarriage in India

Ameet Patki et al. J Obstet Gynaecol India. 2016 Oct.

Abstract

Background: The data on the prevalence of recurrent spontaneous miscarriage (RSM) in India are scarce. This study aimed to determine the prevalence of RSM in Indian females.

Methods: Female patients aged between 18 and 45 years with history of at least one spontaneous miscarriage were enrolled in the study. The probability of a subsequent miscarriage after the first, second, and third miscarriage was determined. The prevalence of RSM (defined as loss of ≥3 pregnancies of ≤20 weeks gestation each) between different age groups was compared using χ (2) test. Binary logistic regression analysis was applied to determine any association between RSM and the presence of risk factors.

Results: Of the 2398 patients screened for eligibility, 767 (32 %) had a history of at least one spontaneous miscarriage. The prevalence of RSM among the 753 enrolled patients who satisfied the eligibility criteria in the study was 7.46 %. RSM was mostly recorded in the age group of ≥33 years (14.68 %, n = 32). In patients with RSM, the second and third miscarriages were more prevalent during 7th week to end of 11th week of gestation. The probability of having a subsequent miscarriage after the first, second, and third miscarriage was 0.25, 0.34, and 0.22, respectively. There was a significant association (p < 0.05) between RSM and clotting disorders, immunological factors, infections, and genetic disorders.

Conclusion: The study revealed a higher prevalence of RSM among the Indian women as compared to western data. Age, clotting disorders, immunological factors, infections, and genetic disorders were the significant risk factors associated with RSM.

Keywords: India; Prevalence; Recurrent spontaneous miscarriage.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Incidence of recurrent spontaneous miscarriage among patients in different age groups
Fig. 2
Fig. 2
Incidence of spontaneous miscarriage (week of gestation) in patients with recurrent spontaneous miscarriages
Fig. 3
Fig. 3
Probability of subsequent miscarriage as per age groups
See this image and copyright information in PMC

References

    1. Li L, Leung PC, Chung TK, et al. Systematic review of Chinese medicine for miscarriage during early pregnancy. Evid Based Complement Altern Med. 2014;2014:753856. - PMC - PubMed
    1. Ford HB, Schust DJ. Recurrent pregnancy loss: etiology, diagnosis, and therapy. Rev Obstet Gynecol. 2009;2(2):76–83. - PMC - PubMed
    1. Li TC, Makris M, Tomsu M, et al. Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update. 2002;8(5):463–481. doi: 10.1093/humupd/8.5.463. - DOI - PubMed
    1. Larsen EC, Christiansen OB, Kolte AM, et al. New insights into mechanisms behind miscarriage. BMC Med. 2013;11:154. doi: 10.1186/1741-7015-11-154. - DOI - PMC - PubMed
    1. Maharana B. Correlates of spontaneous and induced abortion in India: an investigation using a nationwide large scale survey data, Population Association of America. In: 2011 Annual meeting program. http://paa2011.princeton.edu/abstracts/111333. Accessed 25 Feb 2015.

LinkOut - more resources