Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature

Abstract

Feline chronic gingivostomatitis (FCGS) is a disease characterized by protracted and potentially debilitating oral inflammation in cats, the etiology of which is currently unknown. The purpose of this review is to apply an evidence-based medicine approach to systematically review and critically evaluate the scientific literature reporting the outcome of medical and surgical management of FCGS. Those articles meeting inclusion criteria were reviewed and assigned an "Experimental Design Grade" (EDG) and an "Evidence Grade" (EG) in order to score relative strength of study design and produced data. Studies were evaluated and compared, especially highlighting the treatments, the outcomes, and the therapeutic success rates. This review found a lack of consistency between articles' data, rendering direct comparison of results unreliable. The field of FCGS research, and ultimately patient care, would benefit from standardizing studies by adopting use of a consistent semi-quantitative scoring system and extending follow-up duration. Future researchers should commit to large prospective studies that compare existing treatments and demonstrate the promise of new treatments.

Keywords: feline chronic gingivostomatitis; management; stomatitis; systematic review; therapy.

Figure 1

Flowchart modified from the “Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) (35) guidelines,” demonstrating the process by which the search results were narrowed to the 16 articles included in this systematic review.