Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul;31(7):472-8.
doi: 10.1590/S0102-865020160070000007.

The acute effects of preoperative ozone theraphy on surgical wound healing

Hasan Sahin  1 , Tuncer Simsek  1 , Hakan Turkon  2 , Yıldıray Kalkan  3 , Faruk Ozkul  4 , M Turgut Alper Ozkan  5 , Mesut Erbas  6 , Ugur Altinisik  1 , Yavuz Demiraran  7
Affiliations
Free article

The acute effects of preoperative ozone theraphy on surgical wound healing

Hasan Sahin et al. Acta Cir Bras. 2016 Jul.
Free article

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Acta Cir Bras. 2016 Aug;31(8):569. doi: 10.1590/S0102-86502016008ERRATUM. Acta Cir Bras. 2016. PMID: 27579886

Abstract

Purpose: To investigate the effects of preoperative rectal ozone insufflation on surgical wound healing over the proinflammatory cytokines and histopathological changes.

Methods: Twenty one rabbits were divided into 3 groups. Sham, surgical wound, and ozone applied (6 sessions, every other day 70 µg/mL in 12 mL O2-O3 mixture rectally) surgical wound groups were created. TNF-alpha and IL-6 levels from all rabbits were studied at the basal, 24th hour, and 72nd hour. The histopathological examination was done by removing the surgical scar tissue at the end of 72nd hour.

Results: TNF-alfa and IL-6 levels were significantly lower compared to the control group, in the rabbits treated with ozone. The increase in angiogenesis, the decrease in the number of inflammatory cells, epidermal and dermal regeneration, better collagen deposition, and increased keratinisation in stratum corneum were observed in the histopathological examination. It was determined that the wound healing noticeably accelerated in the ozone group.

Conclusion: Preoperative rectal ozone insufflation had a positive effect on surgical wound healing in acute period.

PubMed Disclaimer