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Review
. 2016 Aug 4;11(1):121.
doi: 10.1186/s13019-016-0518-8.

Adenomyoepithelioma of the breast with late pulmonary metastases - case report and review of the literature

Agnieszka Korolczuk  1 , Magdalena Amarowicz  2 , Kamila Bąk  2 , Elżbieta Korobowicz  2 , Tomasz Koncewicz  3
Affiliations
Review

Adenomyoepithelioma of the breast with late pulmonary metastases - case report and review of the literature

Agnieszka Korolczuk et al. J Cardiothorac Surg. .

Abstract

Background: Adenomyoepithelioma (AME) of the breast is a rare tumour of unpredictable clinical behaviour. Most of the tumours are benign with some giving local recurrences or distant metastases.

Case presentation: We report a case of late lung metastases in a woman with a history of breast adenomyoepithelioma. Partial lobectomy was performed for lung lesions and initial diagnosis was epithelial-myoepithelial carcinoma.

Conclusion: Careful slide's revision of both breast and pulmonary lesions showed identical microscopic appearance with lung tumour performing more malignant features. Tumour cells in both: breast and pulmonary lesions were positive for cytokeratin and EMA (epithelial cells) and also for SMA, S100 and vimentin (myoepithelial cells). Two years and 7 months follow-up showed no recurrent neoplastic disease in our patient.

Keywords: Adenomyoepithelioma; Breast; Epithelial-myoepithelial carcinoma; Lung.

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Figures

Fig. 1
Fig. 1
Lung tumour: Metastatic adenomyoepithelioma with component of epithelial-myoepithelial carcinoma. a PET-CT scan: Two nodular masses located in right lower (measuring 26x31mm) and middle lobe (diameter 96 mm). b Light microscope. Inner layer of glandular structures lined by epithelial cells, outer layer formed by myoepithelial cells with clear cytoplasm, mild nuclear atypia and some nucleoli visible. Homogenous, hyalinised stroma. H + E x400. c Immunochistochemical staining for cytokeratin positive in epithelial cells. x400. d Immunochistochemical staining for SMA positive in myoepithelial cells. x400
Fig. 2
Fig. 2
Breast tumour: Adenomyoepithelioma. a, b Light microscope. Inner layer of glandular structures lined by epithelial cells, outer layer formed by myoepithelial cells with clear cytoplasm, mild nuclear atypia and single mitotic figures. Homogenous, hyalinised stroma. H + E x400. c Immunochistochemical staining for SMA positive in myoepithelial cells. x400. d Immunochistochemical staining for cytokeratin positive in epithelial cells. x400
See this image and copyright information in PMC

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