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. 2017 Feb;32(1):77-86.
doi: 10.1007/s11011-016-9881-3. Epub 2016 Aug 3.

A longitudinal study of patients with cirrhosis treated with L-ornithine L-aspartate, examined with magnetization transfer, diffusion-weighted imaging and magnetic resonance spectroscopy

Vijay P B Grover  1   2 , Mark J W McPhail  1   2 , Marzena Wylezinska-Arridge  1   2 , Mary M E Crossey  1 , Julie A Fitzpatrick  1   2 , Louise Southern  1 , Brian K Saxby  3 , Nicola A Cook  1 , I Jane Cox  4 , Adam D Waldman  2 , Novraj S Dhanjal  5 , Aluel Bak-Bol  1   2 , Roger Williams  4 , Marsha Y Morgan  6 , Simon D Taylor-Robinson  7
Affiliations

A longitudinal study of patients with cirrhosis treated with L-ornithine L-aspartate, examined with magnetization transfer, diffusion-weighted imaging and magnetic resonance spectroscopy

Vijay P B Grover et al. Metab Brain Dis. 2017 Feb.

Abstract

The presence of overt hepatic encephalopathy (HE) is associated with structural, metabolic and functional changes in the brain discernible by use of a variety of magnetic resonance (MR) techniques. The changes in patients with minimal HE are less well documented. Twenty-two patients with well-compensated cirrhosis, seven of whom had minimal HE, were examined with cerebral 3 Tesla MR techniques, including T1- and T2-weighted, magnetization transfer and diffusion-weighted imaging and proton magnetic resonance spectroscopy sequences. Studies were repeated after a 4-week course of oral L-ornithine L-aspartate (LOLA). Results were compared with data obtained from 22 aged-matched healthy controls. There was no difference in mean total brain volume between patients and controls at baseline. Mean cerebral magnetization transfer ratios were significantly reduced in the globus pallidus and thalamus in the patients with cirrhosis irrespective of neuropsychiatric status; the mean ratio was significantly reduced in the frontal white matter in patients with minimal HE compared with healthy controls but not when compared with their unimpaired counterparts. There were no significant differences in either the median apparent diffusion coefficients or the mean fractional anisotropy, calculated from the diffusion-weighted imaging, or in the mean basal ganglia metabolite ratios between patients and controls. Psychometric performance improved in 50 % of patients with minimal HE following LOLA, but no significant changes were observed in brain volumes, cerebral magnetization transfer ratios, the diffusion weighted imaging variables or the cerebral metabolite ratios. MR variables, as applied in this study, do not identify patients with minimal HE, nor do they reflect changes in psychometric performance following LOLA.

Keywords: Cirrhosis; Hepatic encephalopathy; Magnetic resonance imaging; Spectroscopy.

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Figures

Fig. 1
Fig. 1
Regional cerebral Magnetisation Transfer Ratios in healthy controls and in patients with cirrhosis, by neuropsychiatric status. Data are presented as median (IQR). Significance of the difference from healthy controls *p < 0.05, **p < 0.01, ***p < 0.001
See this image and copyright information in PMC

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