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. 2016 Sep 21;45(35):13671-4.
doi: 10.1039/c6dt02456d. Epub 2016 Aug 4.

Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery

Isabela Cristina Aguiar de Souza  1 , Leticia Villafranca Faro, Carlos Basilio Pinheiro, Daniel Tadeu Gomes Gonzaga, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Fabio da Silva Miranda, Marciela Scarpellini, Mauricio Lanznaster
Affiliations

Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery

Isabela Cristina Aguiar de Souza et al. Dalton Trans. .

Abstract

Three novel cobalt(iii)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py2en, py2enMe2) on the electronic properties and reactivity of their complexes was observed. An [O2]-dependent reduction to cobalt(ii) by ascorbic acid provided evidence of hypoxic selectivity.

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