Dyspepsia and the microbiome: time to focus on the small intestine

Laurie Zhong^{1

2

3}, Erin R Shanahan^{2

3

4}, Ashok Raj^{2

3}, Natasha A Koloski^{2

5}, Linda Fletcher^{2

3}, Mark Morrison⁴, Marjorie M Walker⁵, Nicholas J Talley⁵, Gerald Holtmann^{2

3}

Affiliations

¹ School of Population Health, University of Queensland, Brisbane, Queensland, Australia.
² Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland, Australia.
³ School of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.
⁴ Microbial Biology and Metagenomics Research Group, Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.
⁵ Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.

Comment

Laurie Zhong et al. Gut. 2017 Jun.

. 2017 Jun;66(6):1168-1169.

doi: 10.1136/gutjnl-2016-312574. Epub 2016 Aug 3.

¹ School of Population Health, University of Queensland, Brisbane, Queensland, Australia.
² Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland, Australia.
³ School of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.
⁴ Microbial Biology and Metagenomics Research Group, Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.
⁵ Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.

No abstract available

Keywords: DUODENAL MUCOSA; FUNCTIONAL DYSPEPSIA; INTESTINAL MICROBIOLOGY; PROTON PUMP INHIBITION.

Comment on

Proton pump inhibitors affect the gut microbiome.
Imhann F, Bonder MJ, Vich Vila A, Fu J, Mujagic Z, Vork L, Tigchelaar EF, Jankipersadsing SA, Cenit MC, Harmsen HJ, Dijkstra G, Franke L, Xavier RJ, Jonkers D, Wijmenga C, Weersma RK, Zhernakova A. Imhann F, et al. Gut. 2016 May;65(5):740-8. doi: 10.1136/gutjnl-2015-310376. Epub 2015 Dec 9. Gut. 2016. PMID: 26657899 Free PMC article.
Proton pump inhibitors alter the composition of the gut microbiota.
Jackson MA, Goodrich JK, Maxan ME, Freedberg DE, Abrams JA, Poole AC, Sutter JL, Welter D, Ley RE, Bell JT, Spector TD, Steves CJ. Jackson MA, et al. Gut. 2016 May;65(5):749-56. doi: 10.1136/gutjnl-2015-310861. Epub 2015 Dec 30. Gut. 2016. PMID: 26719299 Free PMC article.