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. 2016 Apr 26;14(2):131-5.
doi: 10.1016/j.aju.2016.01.006. eCollection 2016 Jun.

Single versus multiple instillation of povidone iodine and urographin in the treatment of chyluria: A prospective randomised study

Mohammed M Seleem  1 , Ahmed M Eliwa  1 , Ehab R Elsayed  1 , Hamdy Desouky  1 , Hazem El Galaly  1 , Khalid Abdelwahab  1 , Salem Khalil  1 , Mahmoud El Adl  1
Affiliations

Single versus multiple instillation of povidone iodine and urographin in the treatment of chyluria: A prospective randomised study

Mohammed M Seleem et al. Arab J Urol. .

Abstract

Objective: To compare the safety, efficacy and complications of single vs multiple instillations of povidone iodine (PI) and urographin as a sclerosing agent in the treatment of chyluria.

Patients and methods: The study included 58 patients diagnosed with chyluria between March 2006 and January 2013. The inclusion criteria were either severe attacks of chyluria or patients with mild-to-moderate chyluria who had failed conservative treatment. The patients were randomly allocated to one of two groups: those in Group A had a single instillation of a combination of PI 0.2% plus the contrast-agent urographin 76%, while those in Group B had multiple instillations of the same combination twice daily for 3 successive days.

Results: The mean (SD) age of the patients in Groups A and B was 38.22 (10.67) and 37.9 (10.86) years, respectively. Chyluria was severe in eight patients (14.8%), moderate in 25 (46.3%) and mild in 21 (38.9%). The success rate in Group A (single instillation) was 85.2% and in Group B (multiple instillation) was 88.9%. The recurrence rate in Group A was 14.8% with a disease-free duration (DFD) of 4-15 weeks, while in group B it was 11.1% with a DFD of 6-18 weeks.

Conclusion: There was no significant difference between a single instillation of a combination of PI 0.2% and urographin 76% as a sclerosing agent in the treatment of chyluria and multiple instillations. However, the single instillation protocol is more cost effective with a shorter hospital stay.

Keywords: Chyluria; Complication; DFD, Disease-free duration; PI, Povidone iodine; Povidone iodine; RPIS, Retrograde pelvic instillation of sclerosing agent; Safety; Urographin.

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Figures

Figure 1
Figure 1
Chyle efflux from a left ureteric orifice.
Figure 2
Figure 2
Study flowchart.
Figure 3
Figure 3
Retrograde pyelography showing pyelolymphatic reflux.
See this image and copyright information in PMC

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