Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Nov;36(6):239-46.
doi: 10.14402/jkamprs.2014.36.6.239. Epub 2014 Nov 12.

Membranes for the Guided Bone Regeneration

Sang-Woon Lee  1 , Seong-Gon Kim
Affiliations
Review

Membranes for the Guided Bone Regeneration

Sang-Woon Lee et al. Maxillofac Plast Reconstr Surg. 2014 Nov.

Abstract

Many kinds of membrane have been used for the guided bone regeneration (GBR) technique. However, most membranes do not fulfill all requirements for the ideal membrane for the GBR technique. Among them, collagen membrane has been most widely used. However, its high price and weak tensile strength in wet condition are limitations for wide clinical application. Synthetic polymers have also been used for the GBR technique. Recently, silk based membrane has been considered as a membrane for the GBR technique. Despite many promising preclinical data for use of a silk membrane, clinical data regarding the silk membrane has been limited. However, silk based material has been used clinically as vessel-tie material and an electrospun silk membrane was applied successfully to patients. No adverse effect related to the silk suture has been reported. Considering that silk membrane can be provided to patients at a cheap price, its clinical application should be encouraged.

Keywords: Bone; Collagen; Membrane; Polymer; Silk.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Scanning electron microscopic view of collagen membrane.
Fig. 2.
Fig. 2.
Scanning electron microscopic view of expanded polytetrafluoroethylene membrane.
Fig. 3.
Fig. 3.
Foreign body giant cells were attached to the silk implants (H&E, ×200).
Fig. 4.
Fig. 4.
Schematic drawing of the electrospun technique.
Fig. 5.
Fig. 5.
Film type silk membrane was encapsulated by fibrotic tissue. Below the silk membrane, new bone formation was observed (H&E, ×100).
Fig. 6.
Fig. 6.
Scanning electron microscopic view of silk membrane.
Fig. 7.
Fig. 7.
The stress-strain curve of each membrane. It was measured in the dry state. Silk membranes were separated according to inner, middle, and outer layer. ePTFE, expanded polytetrafluoroethylene.
Fig. 8.
Fig. 8.
New bone formation below silk membrane. Foreign body giant cells were attached to the silk membrane, but the inflammatory reaction was not severe (Masson trichrome stain, ×100).
See this image and copyright information in PMC

References

    1. Nguyen TT, Mui B, Mehrabzadeh M, et al. Regeneration of tissues of the oral complex: current clinical trends and research advances. J Can Dent Assoc. 2013;79:d1. - PubMed
    1. Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K. Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications. J Prosthodont Res. 2013;57:3–14. - PubMed
    1. Khojasteh A, Morad G, Behnia H. Clinical importance of recipient site characteristics for vertical ridge augmentation: a systematic review of literature and proposal of a classification. J Oral Implantol. 2013;39:386–98. - PubMed
    1. Corinaldesi G, Lizio G, Badiali G, Morselli-Labate AM, Marchetti C. Treatment of intrabony defects after impacted mandibular third molar removal with bioabsorbable and non-resorbable membranes. J Periodontol. 2011;82:1404–13. - PubMed
    1. Cortellini P, Tonetti MS. Clinical performance of a regenerative strategy for intrabony defects: scientific evidence and clinical experience. J Periodontol. 2005;76:341–50. - PubMed

LinkOut - more resources