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Review
. 2016 Aug 4;12(8):e1006196.
doi: 10.1371/journal.pgen.1006196. eCollection 2016 Aug.

Functional Translational Readthrough: A Systems Biology Perspective

Fabian Schueren  1 , Sven Thoms  1
Affiliations
Review

Functional Translational Readthrough: A Systems Biology Perspective

Fabian Schueren et al. PLoS Genet. .

Erratum in

Abstract

Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Systems biology uncovers translational readthrough in humans.
Readthrough genes have been identified with varying levels of experimental confirmation. Gene symbols of gene products known to undergo functional translational readthrough (FTR) are depicted in bold. Circle sizes do not correspond to the number of analyzed genes. Black circles refer to approaches other than systems approaches.
See this image and copyright information in PMC

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