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Review
. 2016 Aug;17(8 Suppl 1):S266-71.
doi: 10.1097/PCC.0000000000000796.

Sepsis in Pediatric Cardiac Intensive Care

Derek S Wheeler  1 , Hector R Wong
Affiliations
Review

Sepsis in Pediatric Cardiac Intensive Care

Derek S Wheeler et al. Pediatr Crit Care Med. 2016 Aug.

Abstract

Objectives: In this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early diagnosis, in monitoring therapeutic efficacy, in stratification, and for the identification of sepsis endotypes; and the pathophysiology and management of severe sepsis and septic shock, with an emphasis on the impact of sepsis on cardiovascular function.

Data source: MEDLINE and PubMed.

Conclusions: There is a lot of excitement in the field of sepsis research today. Scientific advances in the diagnosis and clinical staging of sepsis, as well as a personalized approach to the treatment of sepsis, offer tremendous promise for the future. However, at the same time, it is also evident that sepsis mortality has not improved enough, even with progress in our understanding of the molecular pathophysiology of sepsis.

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References

    1. Black RE, Cousens S, Johnson HL, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010;375:1969–1987. - PubMed
    1. Watson RS, Carcillo JA, Linde-Zwirble WT, et al. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med. 2003;167:695–701. - PubMed
    1. Proulx F, Fayon M, Farrell CA. Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest. 1996;109:1033–1037. - PubMed
    1. ACCP and SCCM: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864–874. - PubMed
    1. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2–8. - PubMed

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