Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep 26;55(40):12148-9.
doi: 10.1002/anie.201606701. Epub 2016 Aug 4.

Balancing C=C Functionalization and C=O Reduction in Cu-H Catalysis

Jens Mohr  1 , Martin Oestreich  2
Affiliations

Balancing C=C Functionalization and C=O Reduction in Cu-H Catalysis

Jens Mohr et al. Angew Chem Int Ed Engl. .

Abstract

Coppercabana: The copper(I) hydride catalyzed functionalization of unactivated alkenes has been shown to be compatible with conventional carbonyl reduction. Through the combination of both pathways or complete suppression of C=O reduction in favor of C=C functionalization, methods for the stereoselective synthesis of a variety of chiral molecules have been developed.

Keywords: asymmetric catalysis; copper catalysis; copper hydride; hydrosilanes; reduction.

PubMed Disclaimer

LinkOut - more resources