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. 2016 Sep:113:170-4.
doi: 10.1016/j.fitote.2016.07.019. Epub 2016 Aug 2.

New sesquiterpene lactones from Ambrosia cumanensis Kunth

Nora Del Socorro Jimenez-Usuga  1 , Nicola Malafronte  2 , Roberta Cotugno  2 , Marinella De Leo  3 , Edison Osorio  1 , Nunziatina De Tommasi  4
Affiliations

New sesquiterpene lactones from Ambrosia cumanensis Kunth

Nora Del Socorro Jimenez-Usuga et al. Fitoterapia. 2016 Sep.

Abstract

Eleven sesquiterpene lactones, including three new natural products (1-3), were isolated from the n-butanolic extract of Ambrosia cumanensis Kunth. aerial parts. The structure of all isolated compounds was elucidated by 1D- and 2D-NMR, and MS analyses. All compounds were tested for their antiproliferative activity on HeLa, Jurkat, and U937 cell lines. Compound 3, 2,3-dehydropsilostachyn C, showed cytotoxic activity with different potency in all cell lines. By means of flow cytometric studies, compound 3 was demonstrated to induce in Jurkat cells a G2/M cell cycle block, while in U937 elicited both cytostatic and cytotoxic responses.

Keywords: Ambrosia cumanensis; Asteraceae; Cytotoxic activity; Sesquiterpene lactones.

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