Arguing against the proposed definition changes of PD

Bradley F Boeve¹, Dennis W Dickson², John E Duda³, Tanis J Ferman⁴, Douglas R Galasko⁵, James E Galvin⁶, Jennifer G Goldman⁷, John H Growdon⁸, Howard I Hurtig³, Daniel I Kaufer⁹, Kejal Kantarci¹⁰, James B Leverenz¹¹, Carol F Lippa¹², Oscar L Lopez¹³, Ian G McKeith¹⁴, Andrew B Singleton¹⁵, Angela Taylor¹⁶, Debby Tsuang¹⁷, Daniel Weintraub¹⁸, Cyrus P Zabetian¹⁹

Affiliations

¹ Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
² Departments of Pathology and Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
³ Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
⁴ Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA.
⁵ Department of Neurosciences, University of California, San Diego, California, USA.
⁶ Marcus Neuroscience Institute, Florida Atlantic University, Boca Raton, Florida, USA.
⁷ Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
⁸ Department of Neurology, Harvard Medical School at Massachusetts General Hospital, Boston, Massachusetts, USA.
⁹ Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
¹⁰ Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
¹¹ Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
¹² Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
¹³ Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁴ Institute of Ageing, Newcastle University, Newcastle upon Tyne, UK.
¹⁵ Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
¹⁶ Lewy Body Dementia Association, Lilburn, Georgia, USA.
¹⁷ Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
¹⁸ Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁹ Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA.

PMID: 27492190
PMCID: PMC5168716
DOI: 10.1002/mds.26721

Comment

Arguing against the proposed definition changes of PD

Bradley F Boeve et al. Mov Disord. 2016 Nov.

. 2016 Nov;31(11):1619-1622.

doi: 10.1002/mds.26721. Epub 2016 Aug 5.

Authors

Affiliations

¹ Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
² Departments of Pathology and Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
³ Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
⁴ Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA.
⁵ Department of Neurosciences, University of California, San Diego, California, USA.
⁶ Marcus Neuroscience Institute, Florida Atlantic University, Boca Raton, Florida, USA.
⁷ Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
⁸ Department of Neurology, Harvard Medical School at Massachusetts General Hospital, Boston, Massachusetts, USA.
⁹ Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
¹⁰ Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
¹¹ Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
¹² Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
¹³ Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁴ Institute of Ageing, Newcastle University, Newcastle upon Tyne, UK.
¹⁵ Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
¹⁶ Lewy Body Dementia Association, Lilburn, Georgia, USA.
¹⁷ Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
¹⁸ Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁹ Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA.

PMID: 27492190
PMCID: PMC5168716
DOI: 10.1002/mds.26721

Abstract

As members of the Lewy Body Dementia Association Scientific Advisory Council, we aim to address some of the issues raised in the article titled "Time to Redefine PD? Introductory Statement of the MDS Task Force on the Definition of Parkinson's Disease." In particular, we suggest that the 1-year rule distinguishing Parkinson's disease dementia from dementia with Lewy bodies is worth maintaining because it serves an important purpose in clinical practice and clinical and basic science research and when helping the lay community understand the complexity of these different clinical phenotypes. Furthermore, we believe that adding an additional diagnostic label, "PD (dementia with Lewy bodies subtype)," will confuse rather than clarify the distinction between dementia with Lewy bodies and PD or PD dementia, and will not improve management or expedite therapeutic development. We present arguments supporting our contentions. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Keywords: Dementia with Lewy bodies; Parkinson's disease; dementia; parkinsonism.

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Comment on

Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease.
Berg D, Postuma RB, Bloem B, Chan P, Dubois B, Gasser T, Goetz CG, Halliday GM, Hardy J, Lang AE, Litvan I, Marek K, Obeso J, Oertel W, Olanow CW, Poewe W, Stern M, Deuschl G. Berg D, et al. Mov Disord. 2014 Apr;29(4):454-62. doi: 10.1002/mds.25844. Epub 2014 Mar 11. Mov Disord. 2014. PMID: 24619848 Free PMC article. Review.

References

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Arguing against the proposed definition changes of PD

Affiliations

Arguing against the proposed definition changes of PD

Authors

Affiliations

Abstract

Comment on

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials

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