Medication-induced diabetes mellitus

Abstract

Epidemiological studies and case reports have demonstrated an increased rate of development of diabetes mellitus consequent to taking diverse types of medication. This review explores this evidence linking these medications and development of diabetes and presents postulated mechanisms by which the medications might cause diabetes. Some medications are associated with a reduction in insulin production, some with reduction in insulin sensitivity, and some appear to be associated with both reduction in insulin production and insulin sensitivity.

Keywords: diabetes mellitus; drug-related side effects and adverse reactions; insulin resistance; insulin-secreting cells; metabolic side effects of drugs.