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Review
. 2016:2016:8426874.
doi: 10.1155/2016/8426874. Epub 2016 Jul 14.

An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment

Shijin Xia  1 , Xinyan Zhang  2 , Songbai Zheng  1 , Ramin Khanabdali  3 , Bill Kalionis  3 , Junzhen Wu  1 , Wenbin Wan  4 , Xiantao Tai  5
Affiliations
Review

An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment

Shijin Xia et al. J Immunol Res. 2016.

Abstract

Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression.

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Figures

Figure 1
Figure 1
The relationship between inflamm-aging and diseases.
Figure 2
Figure 2
The mechanisms and regulated signaling pathways of inflamm-aging.
See this image and copyright information in PMC

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