Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir¹, Jay A Tischfield², Robert A King³, Thomas V Fernandez³, Lawrence W Brown⁴, Keun-Ah Cheon⁵, Barbara J Coffey⁶, Sebastian F T M de Bruijn⁷, Lonneke Elzerman⁸, Blanca Garcia-Delgar⁹, Donald L Gilbert¹⁰, Dorothy E Grice¹¹, Julie Hagstrøm¹², Tammy Hedderly¹³, Isobel Heyman¹⁴, Hyun Ju Hong¹⁵, Chaim Huyser¹⁶, Laura Ibanez-Gomez⁶, Young Key Kim¹⁷, Young-Shin Kim¹⁸, Yun-Joo Koh¹⁹, Sodahm Kook²⁰, Samuel Kuperman²¹, Andreas Lamerz²², Bennett Leventhal¹⁸, Andrea G Ludolph²³, Marcos Madruga-Garrido²⁴, Athanasios Maras²⁵, Marieke D Messchendorp²⁶, Pablo Mir²⁷, Astrid Morer²⁸, Alexander Münchau²⁹, Tara L Murphy¹⁴, Thaïra J C Openneer²⁶, Kerstin J Plessen¹², Judith J G Rath⁷, Veit Roessner³⁰, Odette Fründt³¹, Eun-Young Shin⁵, Deborah A Sival³², Dong-Ho Song⁵, Jungeun Song³³, Anne-Marie Stolte³⁴, Jennifer Tübing²⁹, Els van den Ban³⁵, Frank Visscher³⁶, Sina Wanderer³⁰, Martin Woods¹³, Samuel H Zinner³⁷, Matthew W State¹⁸, Gary A Heiman², Pieter J Hoekstra²⁶, Andrea Dietrich²⁶

Affiliations

¹ Rutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USA; University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands. Electronic address: abdulkadir@dls.rutgers.edu.
² Rutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USA.
³ Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
⁴ Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁵ Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea.
⁶ Icahn School of Medicine at Mount Sinai, New York, NY, USA; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
⁷ Haga Teaching Hospital, Department of Neurology, The Hague, The Netherlands.
⁸ Yulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands.
⁹ Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain.
¹⁰ Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
¹¹ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹² Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, Denmark.
¹³ Evelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UK.
¹⁴ Great Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UK.
¹⁵ Hallym University Sacred Heart Hospital, Anyang, South Korea.
¹⁶ De Bascule, AMC Department of Child and Adolescent Psychiatry, Amsterdam, The Netherlands.
¹⁷ Yonsei Bom Clinic, South Korea.
¹⁸ Department of Psychiatry, University of California, San Francisco, USA.
¹⁹ Korea Institute for Children's Social Development, Seoul, South Korea.
²⁰ MyongJi Hospital, Koyang, South Korea.
²¹ University of Iowa Carver College of Medicine, Iowa City, IA, USA.
²² Triversum, Center for Child and Adolescent Psychiatry, Alkmaar, The Netherlands.
²³ University of Ulm, Department of Child and Adolescent Psychiatry and Psychotherapy, Ulm, Germany.
²⁴ Sección de Neuropediatría, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
²⁵ Yulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
²⁶ University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands.
²⁷ Unidad de Trastornos del Movimiento, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
²⁸ Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIPABS) and Centro de Investigacion en Red de Salud Mental (CIBERSAM), Spain.
²⁹ Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
³⁰ Department of Child and Adolescent Psychiatry, TU Dresden, Germany.
³¹ University Hospital Medical Center Hamburg-Eppendorf, Hamburg, Germany.
³² University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, The Netherlands.
³³ National Health Insurance Service Ilsan Hospital, Goyang-si, South Korea.
³⁴ Accare, Child and Adolescent Psychiatry, Groningen, The Netherlands.
³⁵ Youth Division, Altrecht, Institute for Mental Health, Utrecht, The Netherlands.
³⁶ Admiraal De Ruyter Ziekenhuis, Department of Neurology, Goes, The Netherlands.
³⁷ University of Washington, Department of Pediatrics, Seattle, WA, USA.

PMID: 27494079
PMCID: PMC5026935
DOI: 10.1016/j.jpsychires.2016.07.017

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir et al. J Psychiatr Res. 2016 Nov.

. 2016 Nov:82:126-35.

doi: 10.1016/j.jpsychires.2016.07.017. Epub 2016 Jul 22.

Authors

Affiliations

¹ Rutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USA; University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands. Electronic address: abdulkadir@dls.rutgers.edu.
² Rutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USA.
³ Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
⁴ Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁵ Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea.
⁶ Icahn School of Medicine at Mount Sinai, New York, NY, USA; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
⁷ Haga Teaching Hospital, Department of Neurology, The Hague, The Netherlands.
⁸ Yulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands.
⁹ Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain.
¹⁰ Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
¹¹ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹² Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, Denmark.
¹³ Evelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UK.
¹⁴ Great Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UK.
¹⁵ Hallym University Sacred Heart Hospital, Anyang, South Korea.
¹⁶ De Bascule, AMC Department of Child and Adolescent Psychiatry, Amsterdam, The Netherlands.
¹⁷ Yonsei Bom Clinic, South Korea.
¹⁸ Department of Psychiatry, University of California, San Francisco, USA.
¹⁹ Korea Institute for Children's Social Development, Seoul, South Korea.
²⁰ MyongJi Hospital, Koyang, South Korea.
²¹ University of Iowa Carver College of Medicine, Iowa City, IA, USA.
²² Triversum, Center for Child and Adolescent Psychiatry, Alkmaar, The Netherlands.
²³ University of Ulm, Department of Child and Adolescent Psychiatry and Psychotherapy, Ulm, Germany.
²⁴ Sección de Neuropediatría, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
²⁵ Yulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
²⁶ University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands.
²⁷ Unidad de Trastornos del Movimiento, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
²⁸ Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIPABS) and Centro de Investigacion en Red de Salud Mental (CIBERSAM), Spain.
²⁹ Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
³⁰ Department of Child and Adolescent Psychiatry, TU Dresden, Germany.
³¹ University Hospital Medical Center Hamburg-Eppendorf, Hamburg, Germany.
³² University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, The Netherlands.
³³ National Health Insurance Service Ilsan Hospital, Goyang-si, South Korea.
³⁴ Accare, Child and Adolescent Psychiatry, Groningen, The Netherlands.
³⁵ Youth Division, Altrecht, Institute for Mental Health, Utrecht, The Netherlands.
³⁶ Admiraal De Ruyter Ziekenhuis, Department of Neurology, Goes, The Netherlands.
³⁷ University of Washington, Department of Pediatrics, Seattle, WA, USA.

PMID: 27494079
PMCID: PMC5026935
DOI: 10.1016/j.jpsychires.2016.07.017

Abstract

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

Keywords: Attention-deficit hyperactivity disorder; Delivery; Obsessive-compulsive disorder; Pregnancy; Prenatal; Tourette syndrome.

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References

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Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Affiliations

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Authors

Affiliations

Abstract

References

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LinkOut - more resources

Full Text Sources

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Medical