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. 2016 Aug 4;63(3):352-4.
doi: 10.1016/j.molcel.2016.07.013.

Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding

Jarno Drost  1 , Hans Clevers  2
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Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding

Jarno Drost et al. Mol Cell. .
Free article

Abstract

Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this issue, Guernet et al. (2016) devised clustered regularly interspaced short palindromic repeats (CRISPR)-barcoding to functionally annotate specific mutations and study clonal evolution in heterogeneous cell populations.

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