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Comment
. 2016 Aug 4;19(2):146-148.
doi: 10.1016/j.stem.2016.07.007.

Mesoderm, Cooked Up Fast and Served to Order

Michael Kyba  1
Affiliations
Comment

Mesoderm, Cooked Up Fast and Served to Order

Michael Kyba. Cell Stem Cell. .

Abstract

New sequencing technologies have made it possible to interrogate with unprecedented depth the intrinsic changes experienced by cells as they transit the arena of development. Recently in Cell, Loh, Chen, and colleagues investigated early lineage-restricted human mesoderm cell types and their precursors going back to pluripotency (Loh et al., 2016).

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Figures

Figure 1.
Figure 1.
Differentiation of various mesodermal lineages in vitro. Signaling interventions that drive patterning of mesoderm often show very tight temporal dependencies. WNT signaling for example alternates multiple times along several lineages. The protocol also features paired combinations of agonist and inhibitor at branch points, e.g. BMP inhibitor/agonist for paraxial vs. lateral mesoderm and HH inhibitor/agonist for dermomyotome vs. sclerotome. Mesoderm cells are generally mesenchymal in morphology, however note the transient epithelialization associated with somitogenesis.
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