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. 2016 Aug 16;113(33):9145-7.
doi: 10.1073/pnas.1610992113. Epub 2016 Aug 5.

Mosquitoes boost body armor to resist insecticide attack

Chris Bass  1 , Christopher M Jones  2
Affiliations

Mosquitoes boost body armor to resist insecticide attack

Chris Bass et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Hypothetical model for cuticular resistance in Anopheles mosquitoes. Cartoon cross-sections of the integument of an insecticide-susceptible mosquito and an insecticide-resistant mosquito, respectively, are shown. The cuticle comprises the relatively thin CHC-rich epicuticle and the thicker procuticle. CHCs (represented by black dots) are produced in specialized cells called oenocytes found associated with the epidermis or fat body. The final step of CHC synthesis is catalyzed by CYP4G P450s (represented by red circles), with CHCs then transported to the epicuticle. Resistant An. arabiensis mosquitoes (B) produce up to fourfold more CYP4G16 than susceptible mosquitoes (A), and this finding may explain the enhanced CHC synthesis and thickening of the epicuticle observed in resistant mosquitoes.
See this image and copyright information in PMC

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References

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    1. Balabanidou V, et al. Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae. Proc Natl Acad Sci USA. 2016;113:9268–9273. - PMC - PubMed

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