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. 2016 Aug 16;113(33):9136-8.
doi: 10.1073/pnas.1610336113. Epub 2016 Aug 5.

ORChestrating the human DNA replication program

David M MacAlpine  1
Affiliations

ORChestrating the human DNA replication program

David M MacAlpine. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
ORC density is a determinant of replication timing and genome stability. Schematic of ORC localization in early- and late-replicating domains. ORC localizes to open and accessible chromatin marked by DNase I accessibility, transcription factor (TF) occupancy, and activating chromatin modifications. Late-replicating domains have decreased ORC density and frequently give rise to chromosomal fragile sites.
See this image and copyright information in PMC

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References

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