Textile Processes for Engineering Tissues with Biomimetic Architectures and Properties

Afsoon Fallahi¹, Ali Khademhosseini², Ali Tamayol³

Affiliations

¹ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Polymer Engineering and Color Technology, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Avenue, P.O. Box 15875-4413, Tehran, Iran.
² Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia; Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea. Electronic address: alik@bwh.harvard.edu.
³ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: atamayol@partners.org.

PMID: 27499277
PMCID: PMC4998055
DOI: 10.1016/j.tibtech.2016.07.001

Textile Processes for Engineering Tissues with Biomimetic Architectures and Properties

Afsoon Fallahi et al. Trends Biotechnol. 2016 Sep.

. 2016 Sep;34(9):683-685.

doi: 10.1016/j.tibtech.2016.07.001. Epub 2016 Aug 4.

Authors

Afsoon Fallahi¹, Ali Khademhosseini², Ali Tamayol³

Affiliations

¹ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Polymer Engineering and Color Technology, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Avenue, P.O. Box 15875-4413, Tehran, Iran.
² Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia; Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea. Electronic address: alik@bwh.harvard.edu.
³ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: atamayol@partners.org.

PMID: 27499277
PMCID: PMC4998055
DOI: 10.1016/j.tibtech.2016.07.001

Abstract

Textile technologies in which fibers containing biological factors and cells are formed and assembled into constructs with biomimetic properties have attracted significant attention in the field of tissue engineering. This Forum article highlights the most prominent advances of the field in the areas of fiber fabrication and construct engineering.

Keywords: biofabrication; biomaterials; fiber-based techniques; scaffolds; textile technologies; tissue engineering..

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Figures

**Figure 1**
Various platforms for engineering cell-laden fibers and constructs. (a) 3D woven scaffolds for cartilage tissue engineering. (i) Fluorescent image of a freshly seeded construct. (ii-iii) Architecture of a typical woven structure formed by interlocking multiple layers of two perpendicularly oriented sets of in-plane fibres in the z-direction; cross-sectional view of the Y–Z plane (ii); cross-sectional view of the X–Z plane (iii) [4]. (b) The use of sacrificial alginate templates for engineering protein-based hydrogels. Schematic of fiber fabrication platform (i) and the fiber formation process (ii). Typical fabricated alginate-protein (gelatin methacryloyl) hybrid fibers Alginate: GelMA (2%:10% w/v) (iii) and GelMA (10%) after alginate removal showing that the overall shape and geometry was presented (iv) [8]. (c) A biomimetic platform for engineering coded fibers (i). Micrographs showing multicomponent fibers (ii), (iii). Fabricated grooved hydrogel fibers for guiding cellular growth (iv) [9]. (d) A microweaving machine for the fabrication of hydrogel-fabrics (i) and a typical fabricated hydrogel fabrics (ii) [10]. (e) centimeter scale hydrogel fabrics with predefined patterns formed using a weaving machine [8]. (f) Fabrication of composite fibers by coating a polymeric fibers with a layer of cell-laden hydrogel (i). A typical composite fiber by two separate layers of microbead-laden hydrogel (ii). Micrograph showing a typical braided construct from composite fibers (iii) [11].

See this image and copyright information in PMC

References

1. Akbari M, et al. Textile Technologies and Tissue Engineering: A Path Toward Organ Weaving. Advanced Healthcare Materials. 2016;5(7):751–766. - PMC - PubMed
1. Tamayol A, et al. Fiber-based tissue engineering: Progress, challenges, and opportunities. Biotechnology Advances. 2013;31(5):669–687. - PMC - PubMed
1. Butcher AL, Offeddu GS, Oyen ML. Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds. Trends in Biotechnology. 2014;32(11):564–570. - PubMed
1. Moutos FT, Freed LE, Guilak F. A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nature Mater. 2007;6(2):162–167. - PubMed
1. Onoe H, Takeuchi S. Cell-laden microfibers for bottom-up tissue engineering. Drug Discovery Today. 2015;20(2):236–246. - PubMed

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Textile Processes for Engineering Tissues with Biomimetic Architectures and Properties

Affiliations

Textile Processes for Engineering Tissues with Biomimetic Architectures and Properties

Authors

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources