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. 2016 May 4;2(6):e75.
doi: 10.1097/TXD.0000000000000586. eCollection 2016 Jun.

Kidney Transplant Outcomes After Primary, Repeat and Kidney After Nonrenal Solid Organ Transplantation: A Single-Center Experience

Puneet Sood  1 , Xiaotian Gao  2 , Rajil Mehta  1 , Douglas Landsittel  3 , Christine Wu  1 , Rabeeya Nusrat  1 , Chethan Puttarajappa  1 , Amit D Tevar  4 , Sundaram Hariharan  1
Affiliations

Kidney Transplant Outcomes After Primary, Repeat and Kidney After Nonrenal Solid Organ Transplantation: A Single-Center Experience

Puneet Sood et al. Transplant Direct. .

Abstract

Background: Improvements in renal allograft outcomes have permitted kidney transplantation after prior kidney allograft failure as well as after nonrenal solid organ transplantation. This study compares renal allograft outcomes in the 3 groups, that is, primary, repeat, and kidney after nonrenal solid organ transplantation, where transplant group was coded as a time-dependent variable.

Methods: We retrospectively reviewed registry data for kidney transplant recipients at University of Pittsburgh Medical Center from January 2000 to December 2011. We compared overall graft survival between the 3 groups using Cox regression modeling. We calculated 1-, 3-, and 5-year graft survival and half-lives for each group where feasible.

Results: The study cohort (N = 2014) consisted of group A (primary kidney transplant, n = 1578, with 7923.2 years of follow-up time), group B (repeat kidney transplant, n = 314, with 1566.7 years of follow-up time) and group C (kidney post-nonrenal solid organ transplant, n = 176, with 844.8 years of follow-up time). Of the 1578 patients in the primary kidney transplant group, 74 later received a repeat transplant and thus also have follow-up counted in the repeat kidney transplant group. The median follow-up was 56, 53, and 55 months, respectively. The 5-year actuarial and death-censored graft survival was 68.69%, 68.79%, and 66.48% and 65.53%, 67.68%, and 62.92%, respectively (P = 0.70). There was no difference in overall graft survival in the Cox-adjusted analysis (group B: odds ratio, 1.02; 95% confidence interval, 0.84-1.26; P = 0.79; group C: odds ratio, 0.96; 95% confidence interval, 0.75-1.23; P = 0.76).

Conclusions: The adjusted kidney graft survivals in the 3 groups were similar.

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Conflict of interest statement

The authors declare no funding or conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Adjusted kidney allograft survival curves for the primary renal transplant, repeat renal and kidney after solid organ transplants. Primary kidney: reference. Repeat kidney: 1.02 (95% CI 0.84-1.26, P = 0.79). Kidney post-solid organ: 0.96 (95% CI, 0.75-1.23; P = 0.76). 95% CI, 95% confidence interval.
FIGURE 2
FIGURE 2
Kidney allograft survival curves for the thoracic and abdominal transplant group.
See this image and copyright information in PMC

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