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. 2016 Sep;22(9):991-3.
doi: 10.1038/nm.4148. Epub 2016 Aug 8.

Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus

Jing He  1 , Xia Zhang  1 , Yunbo Wei  2 , Xiaolin Sun  1 , Yaping Chen  3 , Jun Deng  4 , Yuebo Jin  1 , Yuzhou Gan  1 , Xin Hu  3 , Rulin Jia  1 , Chuanhui Xu  1 , Zhaohua Hou  2 , Yew Ann Leong  3 , Lei Zhu  1 , Jinhong Feng  2 , Yuan An  1 , Yuan Jia  1 , Chun Li  1 , Xu Liu  1 , Hua Ye  1 , Limin Ren  1 , Ru Li  1 , Haihong Yao  1 , Yuhui Li  1 , Shi Chen  1 , Xuewu Zhang  1 , Yin Su  1 , Jianping Guo  1 , Nan Shen  4 , Eric F Morand  5 , Di Yu  2   3   4   5 , Zhanguo Li  1
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Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus

Jing He et al. Nat Med. 2016 Sep.

Abstract

Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4(+) T cells. The homeostasis of CD4(+) T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.

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