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. 2016 Dec 1;32(23):3676-3678.
doi: 10.1093/bioinformatics/btw514. Epub 2016 Aug 8.

PRODIGY: a web server for predicting the binding affinity of protein-protein complexes

Li C Xue  1 , João Pglm Rodrigues  1 , Panagiotis L Kastritis  1 , Alexandre Mjj Bonvin  1 , Anna Vangone  1
Affiliations

PRODIGY: a web server for predicting the binding affinity of protein-protein complexes

Li C Xue et al. Bioinformatics. .

Abstract

Gaining insights into the structural determinants of protein-protein interactions holds the key for a deeper understanding of biological functions, diseases and development of therapeutics. An important aspect of this is the ability to accurately predict the binding strength for a given protein-protein complex. Here we present PROtein binDIng enerGY prediction (PRODIGY), a web server to predict the binding affinity of protein-protein complexes from their 3D structure. The PRODIGY server implements our simple but highly effective predictive model based on intermolecular contacts and properties derived from non-interface surface.

Availability and implementation: PRODIGY is freely available at: http://milou.science.uu.nl/services/PRODIGY CONTACT: a.m.j.j.bonvin@uu.nl, a.vangone@uu.nl.

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