A review of recent progress in lens-free imaging and sensing

Abstract

Recently, lens-free imaging has evolved as an alternative imaging technology. The key advantages of this technology, including simplicity, compactness, low cost, and flexibility of integration with other components, have facilitated the realization of many innovative applications, especially, in the fields of the on-chip lens-free imaging and sensing. In this review, we discuss the development of lens-free imaging, from theory to applications. This article includes the working principle of lens-free digital inline holography (DIH) with coherent and semi coherent light, on-chip lens-free fluorescence imaging and sensing, lens-free on-chip tomography, lens-free on-chip gigapixel nanoscopy, detection of nanoparticles using on-chip microscopy, wide field microscopy, and lens-free shadow image based point-of-care systems. Additionally, this review also discusses the lens-free fluorescent imaging and its dependence on structure and optical design, the advantage of using the compact lens-free driven equilibrium Fourier transform (DEFT) resolved imaging technique for on-chip tomography, the pixel super-resolved algorithm for gigapixel imaging, and the lens-free technology for point-of-care applications. All these low-cost, compact, and fast-processing lens-free imaging and sensing techniques may play a crucial role especially in the fields of environmental, pharmaceutical, biological, and clinical applications of the resource-limited settings.

Keywords: CMOS image sensor; Diffraction patterns; From theory to applications; Lens-free imaging and sensing; Shadow images.