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. 2016 Sep 23;60(10):6425-9.
doi: 10.1128/AAC.00838-16. Print 2016 Oct.

Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae

Pranita D Tamma  1 , Yanjie Huang  2 , Belita N A Opene  3 , Patricia J Simner  3
Affiliations

Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae

Pranita D Tamma et al. Antimicrob Agents Chemother. .

Abstract

Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5 μg/ml and meropenem, imipenem, and doripenem MICs of 2 μg/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.

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Figures

FIG 1
FIG 1
Distributions of carbapenem-resistant Enterobacteriaceae carbapenem MICs against carbapenemase producers and non-carbapenemase producers: (A) ertapenem, (B) meropenem, (C) imipenem, and (D) doripenem. Gray bars represent non-carbapenemase producers, and black bars represent carbapenemase producers.
FIG 2
FIG 2
Receiver operating characteristic curves using carbapenem MICs for the detection of carbapenemase-producing carbapenem-resistant Enterobacteriaceae: (A) ertapenem, (B) meropenem, (C) imipenem, and (D) doripenem.
See this image and copyright information in PMC

References

    1. Goodman KE, Simner PJ, Tamma PD, Milstone AM. 2016. Infection control implications of heterogeneous resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE). Expert Rev Infect Ther 14:95–108. doi:10.1586/14787210.2016.1106940. - DOI - PubMed
    1. Chea N, Bulens SN, Knogphet-Tran T, Lynfield R, Shaw KM, Vagnone PS, Kainer MA, Muleta DB, Wilson L, Vaeth E, Dumyati G, Concannon C, Phipps EC, Culbreath K, Janelle SJ, Bamberg WM, Guh AY, Limbago B, Kallen AJ. 2015. Improved phenotype-based definition for identifying carbapenemase-producers among carbapenem-resistant Enterobacteriaceae. Emerg Infect Dis 21:1611–1616. doi:10.3201/eid2109.150198. - DOI - PMC - PubMed
    1. Nordmann P, Naas T, Poirel L. 2011. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 10:1791–1798. - PMC - PubMed
    1. Centers for Disease Control and Prevention. FAQs about choosing and implementing a CRE definition. http://www.cdc.gov/hai/organisms/cre/definition.html Accessed 27 June 2016.
    1. Tijet N, Boyd D, Patel SN, Mulvey MR, Melano RG. 2013. Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother 57:4578–4580. doi:10.1128/AAC.00878-13. - DOI - PMC - PubMed

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