Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep;7(5):671-9.
doi: 10.1016/j.jare.2016.07.001. Epub 2016 Jul 15.

Effect of exercise on serum vitamin D and tissue vitamin D receptors in experimentally induced type 2 Diabetes Mellitus

Yosria E Aly  1 , Azza S Abdou  1 , Mona M Rashad  2 , Menatallah M Nassef  2
Affiliations

Effect of exercise on serum vitamin D and tissue vitamin D receptors in experimentally induced type 2 Diabetes Mellitus

Yosria E Aly et al. J Adv Res. 2016 Sep.

Abstract

This work aimed to study the effect of swimming exercise on serum vitamin D level and tissue vitamin D receptors in experimentally induced type 2 Diabetes Mellitus. Sixty adult male rats were divided into control and diabetic groups. Each was further subdivided into sedentary and exercised subgroups. Diabetes Mellitus was induced by a single intraperitoneal dose of streptozotocin (50 mg/kg) dissolved in cold 0.01 M citrate buffer (pH 4.5). The exercised subgroups underwent swimming for 60 min, 5 times a week for 4 weeks. Serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipids, vitamin D and tissue Vitamin D receptors (VDR) were evaluated. Significant increase in serum glucose, insulin, HOMA-IR, cholesterol, triglycerides, and low density lipoprotein (LDL) levels in sedentary diabetic rats was detected. On the other hand, high density lipoprotein (HDL), free fatty acids, serum vitamin D and pancreatic, adipose, and muscular VDR showed a significant decrease in the same group. It is evident that all these parameters were reversed by swimming exercise indicating its beneficial role in type 2 Diabetes. In diabetic groups; serum vitamin D was found to be correlated negatively with serum glucose, insulin, HOMA, cholesterol, triglycerides, and LDL and positively correlated with HDL and tissue VDR. In conclusion, Disturbed vitamin D is associated with metabolic impairments in sedentary diabetic rats. Moderate swimming exercise is beneficial in improving these consequences through modulation of vitamin D status. Future studies could be designed to investigate the effect of the combination of vitamin D intake with exercise in diabetic patients.

Keywords: Exercise; Serum vitamin D; Swimming; Type 2 Diabetes Mellitus; Vitamin D receptor.

PubMed Disclaimer

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Serum vitamin D (nmol/L) in control and diabetic rats. ∗: Statistically significant at P ⩽ 0.05.
Fig. 2
Fig. 2
Pancreatic vitamin D receptor (VDR) (ng/mL) in control and diabetic rats. ∗: Statistically significant at P ⩽ 0.05.
Fig. 3
Fig. 3
Skeletal muscle vitamin D receptor (VDR) (ng/mL) in control and diabetic rats. ∗: Statistically significant at P ⩽ 0.05.
Fig. 4
Fig. 4
Adipose tissue vitamin D receptor (VDR) (ng/mL) in control and diabetic rats. ∗: Statistically significant at P ⩽ 0.05.
None
See this image and copyright information in PMC

References

    1. Maxwell C., Wood R. Update on vitamin D and type 2 diabetes. Nutr Rev. 2011;69:291–295. - PubMed
    1. Satin L.S., Butler P.C., Ha J., Sherman A.S. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015;42:61–77. - PMC - PubMed
    1. Palomer X., Gonzolez-Clemente M., Bianco-Vaca F., Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes Mellitus. Diabetes Obes Metab. 2008;10:185–197. - PubMed
    1. Al-Shoumer K.A., Al-Essa T.M. Is there a relationship between vitamin D with insulin resistance and diabetes mellitus? World J Diabetes. 2015;6:1057–1064. - PMC - PubMed
    1. Bikle D.D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21:319–329. - PMC - PubMed

LinkOut - more resources