Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul 27;2(7):434-7.
doi: 10.1021/acscentsci.6b00190. Epub 2016 Jul 15.

Does Nanomedicine Have a Delivery Problem?

Michael Torrice

Does Nanomedicine Have a Delivery Problem?

Michael Torrice. ACS Cent Sci. .
No abstract available

PubMed Disclaimer

Figures

None
The enhanced permeability and retention (EPR) effect is supposed to help nanoparticles accumulate in tumors. Because of their size, the particles cannot slip between endothelial cells lining normal blood vessels (top). But tumor tissue often contains leaky vessels that allow nanoparticles to sneak through (bottom), according to EPR theory. Unlike in healthy tissue, tumors lack efficient drainage by the lymphatic system, and this slows the clearance of nanoparticles.
None
Chan’s analysis of the nanomedicine literature reveals small differences in median particle delivery efficiencies over time, by targeting method, and by size. Credit: Nature Reviews Materials.
None
BIND-014 nanoparticles target tumors actively through small molecules (blue) that can bind to proteins on cancer cells or on the blood vessels feeding tumors. The polymer (gray) particles encapsulate anticancer drugs (red) such as docetaxel. Credit: Gaël McGill/Digizyme.
See this image and copyright information in PMC