Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct:20:1-10.
doi: 10.1016/j.coviro.2016.07.009. Epub 2016 Aug 6.

Hepatocarcinogenesis associated with hepatitis B, delta and C viruses

Elham Shirvani-Dastgerdi  1 , Robert E Schwartz  2 , Alexander Ploss  3
Affiliations
Review

Hepatocarcinogenesis associated with hepatitis B, delta and C viruses

Elham Shirvani-Dastgerdi et al. Curr Opin Virol. 2016 Oct.

Abstract

Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.

PubMed Disclaimer

References

    1. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132:1133–1145. - PubMed
    1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–E386. - PubMed
    1. Farci P, Niro GA. Clinical features of hepatitis D. Semin Liver Dis. 2012;32:228–236. - PubMed
    1. Buti M, Homs M, Rodriguez-Frias F, Funalleras G, Jardi R, Sauleda S, Tabernero D, Schaper M, Esteban R. Clinical outcome of acute and chronic hepatitis delta over time: a long-term follow-up study. J Viral Hepat. 2011;18:434–442. - PubMed
    1. Grabowski J, Wedemeyer H. Hepatitis delta: immunopathogenesis and clinical challenges. Dig Dis. 2010;28:133–138. - PubMed

Publication types

MeSH terms