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Review
. 2016 Aug;1378(1):174-179.
doi: 10.1111/nyas.13177. Epub 2016 Aug 9.

Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

Carl J Lacey  1 , Irene Wohlman  2 , Christophe Guillon  1 , Jaya Saxena  1 , Cynthia Fianu-Velgus  1 , Erik Aponte  1 , Sherri C Young  3 , Diane E Heck  4 , Laurie B Joseph  2 , Jeffrey D Laskin  5 , Ned D Heindel  6
Affiliations
Review

Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

Carl J Lacey et al. Ann N Y Acad Sci. 2016 Aug.

Abstract

The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.

Keywords: bifunctionals; chloroethylethylsulfide; inflammation; phorbol ester; skin; sulfur mustard; vesicants.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
General platform design of bifunctional drugs.
See this image and copyright information in PMC

References

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