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Comparative Study
. 2016 Sep 6;115(6):716-24.
doi: 10.1038/bjc.2016.235. Epub 2016 Aug 9.

L1CAM expression in endometrial carcinomas: an ENITEC collaboration study

Louis Jm van der Putten  1 , Nicole Cm Visser  2 , Koen van de Vijver  3 , Maria Santacana  4 , Peter Bronsert  5 , Johan Bulten  2 , Marc Hirschfeld  6   7 , Eva Colas  8 , Antonio Gil-Moreno  8   9 , Angel Garcia  10 , Gemma Mancebo  11 , Fransesc Alameda  12 , Jone Trovik  13 , Reidun K Kopperud  14   15 , Jutta Huvila  16 , Stefanie Schrauwen  17 , Martin Koskas  18 , Francine Walker  19 , Vit Weinberger  20 , Lubos Minar  20 , Eva Jandakova  21 , Marc Plm Snijders  22 , Saskia van den Berg-van Erp  23 , Xavier Matias-Guiu  4 , Helga B Salvesen  13 , Frederic Amant  17 , Leon Fag Massuger  1 , Johanna Ma Pijnenborg  24
Affiliations
Comparative Study

L1CAM expression in endometrial carcinomas: an ENITEC collaboration study

Louis Jm van der Putten et al. Br J Cancer. .

Abstract

Background: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas.

Methods: The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated.

Results: In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs.

Conclusions: The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.

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Figures

Figure 1
Figure 1
Kaplan–Meier plots of the 10-year disease-free and overall survival of the stage I endometrioid, advanced-stage endometrioid, and non-endometrioid cases with respect to L1CAM expression (a full colour version of this figure appears online).
See this image and copyright information in PMC

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