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. 2016 Aug 19;18(16):4148-50.
doi: 10.1021/acs.orglett.6b02154. Epub 2016 Aug 9.

Manganese-Catalyzed Carboacylations of Alkenes with Alkyl Iodides

Caitlin M McMahon  1 , Matthew S Renn  1 , Erik J Alexanian  1
Affiliations

Manganese-Catalyzed Carboacylations of Alkenes with Alkyl Iodides

Caitlin M McMahon et al. Org Lett. .

Abstract

A manganese-catalyzed carboacylation of alkenes with alkyl iodides and carbon monoxide is described. This carbonylative difunctionalization uses both primary and secondary alkyl iodides in reactions with a diverse array of cyclic and acyclic substrates. Examples of successful applications to the synthesis of five-, six-, and seven-membered rings are provided. The inexpensive, first-row catalytic system and mild reaction conditions are expected to facilitate applications in complex synthesis.

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Figures

Figure 1
Figure 1
Metal-catalyzed, carbonylative alkene additions of alkyl iodides.
Scheme 1
Scheme 1
Plausible Catalytic Cycle
See this image and copyright information in PMC

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