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Comment
. 2016 Aug 8;30(2):189-191.
doi: 10.1016/j.ccell.2016.07.012.

Pre-Metastatic Niche Formation Has Taken Its TOLL

Candia M Kenific  1 , Laura Nogués  1 , David Lyden  2
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Pre-Metastatic Niche Formation Has Taken Its TOLL

Candia M Kenific et al. Cancer Cell. .
Free article

Abstract

Pre-Metastatic Niches (PMNs) result from communications between primary tumors and the microenvironment of future distant metastasis via tumor-derived factors. In this issue of Cancer Cell, Liu et al. show that TLR3 activation in lung epithelial cells by tumor exosomal RNAs triggers neutrophil recruitment, which contributes to PMN formation and metastasis.

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