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Review
. 2015 Jul 1:4:176.
doi: 10.12688/f1000research.6665.1. eCollection 2015.

Mitochondrial DNA Damage and Diseases

Gyanesh Singh  1 , U C Pachouri  1 , Devika Chanu Khaidem  1 , Aman Kundu  1 , Chirag Chopra  1 , Pushplata Singh  2
Affiliations
Review

Mitochondrial DNA Damage and Diseases

Gyanesh Singh et al. F1000Res. .

Abstract

Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage. One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency of the mtDNA. mtDNA damage might cause impaired mitochondrial function, and, unrepaired mtDNA damage has been frequently linked with several diseases. Exploration of mitochondrial perspective of diseases might lead to a better understanding of several diseases, and will certainly open new avenues for detection, cure, and prevention of ailments.

Keywords: Oxidative damage; mitochondrial DNA repair; mitochondrial mutations; mitochondrial pathology.

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Conflict of interest statement

Competing interests: No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Mitochondrial DNA damage is associated with various diseases.
See this image and copyright information in PMC

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