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Review
. 2015 Oct 20:4:F1000 Faculty Rev-1092.
doi: 10.12688/f1000research.6548.1. eCollection 2015.

Epigenetic and microRNA regulation during osteoarthritis development

Di Chen  1 , Jie Shen  2 , Tianqian Hui  1
Affiliations
Review

Epigenetic and microRNA regulation during osteoarthritis development

Di Chen et al. F1000Res. .

Abstract

Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to OA development. Potential therapeutic strategies may be developed on the basis of novel findings.

Keywords: Osteoarthritis; epigenetics; methylation; miR-140; miRNA; microRNA.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

No competing interests were disclosed.

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    2. F1000 Recommendation

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