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Comment
. 2016 Aug 9;24(2):200-2.
doi: 10.1016/j.cmet.2016.07.018.

Empagliflozin's Fuel Hypothesis: Not so Soon

Gary D Lopaschuk  1 , Subodh Verma  2
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Comment

Empagliflozin's Fuel Hypothesis: Not so Soon

Gary D Lopaschuk et al. Cell Metab. .
Free article

Abstract

The EMPA-REG OUTCOME trial (Zinman et al., 2015) established cardioprotective effects of empagliflozin in high-risk diabetic patients, but the underlying mechanisms remain elusive. A recent hypothesis proposed that increased ketone oxidation contributed to the effect, but several caveats indicate that the role of myocardial ketone oxidation is far from clear.

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  • Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.
    Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, Mattheus M, Devins T, Johansen OE, Woerle HJ, Broedl UC, Inzucchi SE; EMPA-REG OUTCOME Investigators. Zinman B, et al. N Engl J Med. 2015 Nov 26;373(22):2117-28. doi: 10.1056/NEJMoa1504720. Epub 2015 Sep 17. N Engl J Med. 2015. PMID: 26378978 Clinical Trial.

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