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Review
. 2016 Jul 19;4(7):e3.
doi: 10.2106/JBJS.RVW.15.00086.

Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm

Stephen R Stephan  1 , Brandon Shallop  1 , Richard Lackman  2 , Tae Won B Kim  2 , Mary K Mulcahey  1
Affiliations
Review

Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm

Stephen R Stephan et al. JBJS Rev. .

Abstract

Evidence now exists suggesting a neoplastic origin for pigmented villonodular synovitis, including a thorough description of the translocations involved. Arthroscopic excision for localized pigmented villonodular synovitis allows for both minimal recurrence and morbidity when compared with open excision; however, open excision still plays an important role in treating posterior compartment nodules. The optimal surgical treatment for diffuse pigmented villonodular synovitis is still a matter for debate, with combined anterior arthroscopic and open posterior excision being considered the preferred method. Radiation therapy has re-emerged as an additional treatment method for pigmented villonodular synovitis; however, the potential for serious toxicity makes it a questionable option, especially for such a benign condition. Small molecule and monoclonal antibody targeted therapies are being investigated as novel treatment methods for pigmented villonodular synovitis, with promising results.

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References

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