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. 1989 Aug;79(8):1046-8.
doi: 10.2105/ajph.79.8.1046.

Elimination of cotinine from body fluids: disposition in smokers and nonsmokers

N J Haley  1 , D W Sepkovic, D Hoffmann
Affiliations

Elimination of cotinine from body fluids: disposition in smokers and nonsmokers

N J Haley et al. Am J Public Health. 1989 Aug.

Abstract

We have evaluated differences in the elimination of cotinine, a major nicotine metabolite, in smokers who quit smoking and never-smokers who were exposed to environmental tobacco smoke (ETS) under controlled conditions. The mean biological half-life of cotinine in urine, collected from the nine smokers was 16.5 +/- 1.2 h, in never-smokers exposed to ETS, 27.3 +/- 1.9 h. Differences in the mode of uptake and absorption of nicotine and possible differences in nicotine metabolism may play roles in the clearance rate differences between smokers and nonsmokers.

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