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. 2016 Nov;62(11):893-903.
doi: 10.1139/cjm-2016-0143. Epub 2016 Jun 10.

Characterization of two LuxI/R homologs in Pantoea ananatis LMG 2665T

Siphathele Sibanda  1   2 , Jacques Theron  1 , Divine Y Shyntum  1 , Lucy N Moleleki  1   2 , Teresa A Coutinho  1   2
Affiliations

Characterization of two LuxI/R homologs in Pantoea ananatis LMG 2665T

Siphathele Sibanda et al. Can J Microbiol. 2016 Nov.

Abstract

Quorum sensing (QS) plays an important role in the regulation of bacteria-host interactions and ecological fitness in many bacteria. In this study, 2 luxI/R homologs, namely eanI/eanR and rhlI/rhlR, were identified in the genome sequence of Pantoea ananatis LMG 2665T. To determine a role for these luxI/R homologs in pathogenicity and biofilm formation, mutant bacterial strains lacking either eanI/R or rhlI/R and both of these homologs were generated. The results indicated that both the RhlI/R and EanI/R systems are required for pathogenicity and biofilm formation in strain LMG 2665T. This is the first study to characterize the biological significance of the RhlI/R QS system in P. ananatis.

Keywords: LuxI/R; Pantoea ananatis; détection du quorum; pathogenicity; pathogénicité; quorum sensing.

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