A model of tissue contraction during thermal ablation

Abstract

A model of a globular protein is used to describe the contraction of tissue exposed to elevated temperatures. This will be useful in predicting the contraction of tissue that is observed during thermal ablation of tumours, which is a problem when trying to determine the ablation zone in post-operative images. The transitions between the states of the protein can be related to a change in the length of the molecule, which can be directly observed as a change in the length of the tissue. A three state model of a globular protein is used to describe the contraction of tissue exposed to elevated temperatures. A nonlinear fitting algorithm is considered here to fit available experimental data and thus to obtain the values of the model parameters. A sensitivity analysis of the proposed mathematical model is performed to determine the most important parameters in the model. The model parameters were obtained from experimental data of isothermal free shrinkage experiments. The predictions of the complete model show similar agreement with the data, well within the experimental error of 10%. The overall activation energy and frequency factor were found to be 201 kJ mol(-1) and [Formula: see text] s(-1) respectively. The results show that the experimental data were well described by the three state model considered here. Furthermore, it was possible to determine the most sensitive parameters in the model. The model presented here will allow predictions of thermal ablation to be corrected for tissue shrinkage, thus improving mathematical simulations for treatment planning, although clinical translation will require adapting the model from experimentally obtained tendon data to soft tissue data.